A new, more transmissible monkeypox variant, known as ‘Cload1’, has emerged, raising concerns about its impact on children and pregnant women. This variant, containing two mutations, ‘Cload1A’ and ‘Cload1B’, has been observed to spread rapidly, affecting individuals under the age of 15 and pregnant women primarily through direct contact. The mortality rate for this strain is significantly higher, reaching 5% among men and 10% among children under 15. This new strain has undergone significant evolutionary changes, differing by 96% from the original variant, with eight new mutations detected within a month, contributing to its rapid spread. The virus is particularly contagious when it infects the respiratory system, emphasizing the need for preventive measures like frequent handwashing, safe food handling, and avoiding close contact with infected individuals. While 40% of infected individuals recover spontaneously, severe cases requiring hospitalization and isolation are increasing due to higher viral concentrations in the respiratory system. Common symptoms include headaches, fever, muscle aches, and a characteristic skin rash.